Comparing Weight Loss Medications

Comparing Weight Loss Medications: Mounjaro vs Wegovy, Saxenda & Orlistat

In today’s world, achieving and maintaining a healthy weight can feel like an uphill battle. For many, lifestyle changes alone aren’t enough—and that’s where prescription weight loss medications come in. At Aesthi Clinic | Online Doctor, we help you navigate the options safely and effectively.

Let’s compare four of the most widely used weight loss medications in the UK: Mounjaro, Wegovy, Saxenda, and Orlistat — and explore why Mounjaro is quickly emerging as the standout choice.

Mounjaro (Tirzepatide)

The Game-Changer in Weight Loss

Mounjaro is the newest—and arguably most promising—weight loss injection available. Originally developed to treat type 2 diabetes, it has demonstrated exceptional results in weight loss, often surpassing other medications in clinical trials.

• Mechanism: Dual action on GLP-1 and GIP receptors, enhancing insulin production and reducing appetite

• Dosing: Weekly subcutaneous injection

• Weight Loss Potential: Up to 22.5% of body weight in clinical studies

• Approved For: Type 2 diabetes (with strong off-label use for obesity)

Why We Favour Mounjaro:

Unlike older medications, Mounjaro uniquely targets two hormonal pathways, leading to superior weight loss and appetite control. It’s particularly helpful for individuals struggling with cravings or insulin resistance. Patients report earlier satiety, fewer food-related thoughts, and sustained motivation due to visible progress.

Wegovy (Semaglutide)

Proven Performance, Once Weekly

Wegovy, another GLP-1 agonist, has been a go-to choice since its UK launch in 2023.

• Mechanism: GLP-1 receptor agonist, reducing hunger and increasing feelings of fullness

• Dosing: Weekly subcutaneous injection

• Weight Loss Potential: Up to 15% of body weight

• Approved For: Weight management in patients with obesity or overweight with comorbidities

Considerations:
Wegovy is effective and generally well-tolerated. However, its single-hormone pathway may limit results for some compared to Mounjaro. Still, it’s a solid option, especially for those who respond well to GLP-1 therapies.

Saxenda (Liraglutide)

Daily Injections, Moderate Results

Saxenda paved the way for GLP-1-based weight loss, but it’s now largely overshadowed by newer alternatives.

• Mechanism: GLP-1 receptor agonist

• Dosing: Daily subcutaneous injection

• Weight Loss Potential: Up to 8% of body weight

• Approved For: Weight management

Considerations:
While effective for some, the daily injection schedule can be inconvenient. Weight loss results tend to plateau sooner than with weekly treatments like Mounjaro or Wegovy.

Orlistat (Alli/Xenical)

Over-the-Counter, But Limited

Orlistat is one of the few medications available without a prescription, but it works differently—and with more lifestyle disruption.

• Mechanism: Blocks absorption of dietary fat in the gut

• Dosing: Taken with meals (up to 3x daily)

• Weight Loss Potential: Around 5–7% of body weight

• Approved For: Obesity management

Considerations:
Side effects like urgent bowel movements and oily stools are common if fat intake isn’t strictly controlled. Orlistat doesn’t reduce appetite, making it less suitable for those with emotional or habitual eating patterns.

Which Medication Is Right for You?

The Aesthi Clinic Verdict

At Aesthi Clinic, we stay ahead of the curve—offering evidence-based treatments tailored to your body and goals. Mounjaro is currently the most advanced, powerful weight loss medication available. If you’re looking for maximum results with a once-weekly, clinically proven treatment, Mounjaro should be your top consideration.

Ready to Get Started?

Start your consultation online today and take the first step toward a healthier, more confident you. We’ll guide you safely through your options and provide ongoing support every step of the way.